Route 51 Santa Clara serves Washington-Jefferson Park, River Road Station, North Eugene High School, and Santa Clara Square.
The route begins at Eugene Station (Bay E) and travels North on Olive Street, West on 8th Avenue, North on Washington Street by Washington-Jefferson Park and West onto 1st Avenue. The bus travels onto Railroad Boulevard and turns North onto River Road to stop at River Road Station. North Eugene High School is west of River Road Station on Silver Lane. The bus continues on River Road where it serves Santa Clara Square. The bus turns East on Wilkes Drive, North on Scenic Drive, West on Spring Creek Drive, South on River Road, and East to arrive at River Road Station. The bus travels Southbound on River Road, East on Railroad Boulevard which becomes 1st Avenue, South onto Jefferson Street, East at 5th Avenue, South at Charnelton Street and East at 10th Avenue to return to Eugene Station.