Route 51 Santa Clara serves Washington-Jefferson Park, North Eugene High School, and Santa Clara Square.
The route leaves Eugene Station Bay E and heads North on Olive, West on 8th and turns North on Washington Street and then West onto 1st Avenue. The route segues onto Railroad Boulevard, then turns North onto River Road. It stops at River Road Station, 3 blocks East of North Eugene High School. The bus continues on River Road and serves Santa Clara Square. It continues on River Road before turning East on Wilkes Drive and then North on Scenic Drive, with a short jog on Rover Loop #2, then back North on Scenic Drive. The bus then turns West on Spring Creek, back South on River Road where it heads east to enter the River Road Station, then loops back Southbound onto River Road. The bus goes East on Railroad Boulevard which connects to 1st Ave., then South onto Jefferson, East at 5th Avenue, South at Charnelton, and East at 10th Avenue to the Eugene Station.